My boss recently made the wheels to go on the little truck models I've been working on, and they turned out amazing!
Unfortunately, something neither of us picked up on until after the tires were on was that the back fender's angle that sticks out past the wheels is at a slightly different angle than the tire guard on the other side. It's slight but gives it a weird optical illusion that makes the wheel look slightly off-center. Thankfully it's not super noticeable when the windows and details are cut out after getting anodized, but I was allowed to change it before running the final blocks.
Initially, I was a little afraid to do this, as making modifications to solid models in the past has been anything but a clean process. However, taking advantage of the surface body features in Fusion360, I was able to delete, modify, and remove faces, rather than solid 3D models. This made the change much easier, and there weren't any weird floating bits leftover that I would sometimes get. It also was able to show me very quickly where there was a disconnect on faces/features before taking it into the CAM environment.